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Professional illustrators and graphic artists use drawing software such as Adobe Illustrator and Macromedia Freehand (which is now also owned by Adobe) for book cover design. These programs contain a variety of sophisticated drawing tools that you may find useful, however the learning curve is steep and they can be expensive, particularly if you are only going to use them a few times. There are other options for designing a book cover, such as:
Another option is using a program called BookCoverPro, which is geared toward self publishers who want to design their own covers but don't have the time or skills to use the higher end programs. A membership is under $200 and contains the program, dozens of professional templates and images, user guide, plus a free program to create marketing materials, and the upgrades are free. I use the program and it's very easy to learn and apply.